macuv9lmo1


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The LMO family of genes (Table 1) was uncovered by the finding of the association of LMO1 with a chromosomal translocation t(11;14)(p15;q11) found in human T-cell acute lymphoblastic leukemia (T-ALL). LMO2 and LMO3 were identified by low-stringency hybridization using an LMO1 complementary DNA (cDNA) probe. Subsequently, LMO2 was also found to be associated with a chromosomal translocation t ...

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GeneCards Summary for LMO1 Gene. LMO1 (LIM Domain Only 1) is a Protein Coding gene. Diseases associated with LMO1 include T-Cell Acute Lymphoblastic Leukemia and Exencephaly . Among its related pathways are Gene expression (Transcription) and Assembly of the pre-replicative complex . An important paralog of this gene is LMO3.

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LMO1. Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene. [5] [6] [7] LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.

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Polymorphisms in LMO1 are associated with increased susceptibility to develop neuroblastoma. Here, the authors show that LMO1 directly induces the transcription factor ASCL1, which regulates the ...

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A genome-wide association study identified LMO1, which encodes an LIM-domain-only transcriptional cofactor, as a neuroblastoma susceptibility gene that functions as an oncogene in high-risk neuroblastoma. Here we show that dβh promoter-mediated expression of LMO1 in zebrafish synergizes with MYCN to …

The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self-renewing cancer stem cells are poorly understood. Here, we exploit T-cell acute lymphoblastic leukemia (T-ALL) as a model to define the critical initiating events in this dise …

This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated ...

LMO1 / YLL007C Overview. Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein 1 2.

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